[420 Girl]

LOS ANGELES, Dec. 7 (UPI) -- Marijuana may reduce spasticity -- involuntary muscle contractions -- in multiple sclerosis patients, U.S. researchers said.

The systematic review of six randomized, controlled trials, published in Neurology, found five of the trials reported a reduction in spasticity and an improvement in mobility.

Researchers Shaheen Lakhan and Marie Rowland of the Global Neuroscience Initiative Foundation in Los Angeles said they looked for trials evaluating two marijuana extracts -- delta9-tetrahydrocannabinol -- THC -- and cannabidiol -- CBD.

"We found evidence that combined THC and CBD extracts may provide therapeutic benefit for MS spasticity symptoms," Lakhan said in a statement. "The therapeutic potential of cannabinoids in MS is comprehensive and should be given considerable attention."

The researchers said reported incidence of marijuana side effects -- such as intoxication -- varied greatly depending on the amount of marijuana needed to effectively limit spasticity. However, the researchers noted side effects were also seen in the placebo groups


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